ADVANCED CORONARY PHYSIOLOGY
By Drs Justin E Davies, Ricardo Petraco and Sayan Sen
Imperial College London, 2012
Please feel free to browse the following links to improve your understanding of coronary physiology. The aim of these talks is to expand beyond the scope of the range of topics normally discussed in clinical courses, to aid understanding of how new insights in coronary physiology have origins from the observations of pioneers in the past.
Aim: Understand the mechanisms behind coronary blood flow
Aim: Understand how coronary flow is regulated by changes in coronary contractility as well as resistance
Aim: Understand the rationale and benefits of the wave-free period for assessment of coronary stenoses
Aim: Understand the origins of physiological assessment of coronary stenoses
Aim: Introduction to two new indices for evaluation of coronary stenosis severity without the need for hyperaemia
6. ADVISE study
Aim: Understand the rationale, study design, methods and interpretation of the first-in-man evaluation of iFR.
Aim: Understand the rationale for this study, and interpretation of the results of this real world application of iFR
Aim: Potential for application of iFR and FFR in clinical practice
Aim: Assessment of iFR in a prospective, independent, blinded study cohort.
10. CLARIFY study
Aim: Assessment of impact of adenosine administration on diagnostic categoristaion using iFR and FFR.
Aim: Understand the physiological rationale for differences in classification between different physiological indices
Aim: Understand whatÕs needed to measure iFR reliably
ADVISE study – Sayan Sen
Development and validation of a new adenosine-independent index of stenosis severity from coronary wave-intensity analysis: results of the ADVISE (ADenosine Vasodilator Independent Stenosis Evaluation) study.
Sen S, Escaned J, Malik IS, Mikhail GW, Foale RA, Mila R, Tarkin J, Petraco R, Broyd C, Jabbour R, Sethi A, Baker CS, Bellamy M, Al-Bustami M, Hackett D, Khan M, Lefroy D, Parker KH, Hughes AD, Francis DP, Di Mario C, Mayet J, Davies JE.
J Am Coll Cardiol. 2012 Apr 10;59(15):1392-402. doi: 10.1016/j.jacc.2011.11.003. Epub 2011 Dec 7.
ADVISE Editorial – Morton Kern
An adenosine-independent index of stenosis severity from coronary wave-intensity analysis: a new paradigm in coronary physiology for the cath lab?
J Am Coll Cardiol. 2012 Apr 10;59(15):1403-5. doi: 10.1016/j.jacc.2011.11.006. Epub 2011 Dec 7.
ADVISE-Registry – Ricardo Petraco
Classification performance of instantaneous wave-free ratio (iFR) and fractional flow reserve in a clinical population of intermediate coronary stenoses: results of the ADVISE registry.
Petraco R, Escaned J, Sen S, Nijjer S, Asrress KN, Echavarria-Pinto M, Lockie T, Khawaja MZ, Cuevas C, Foin N, Broyd C, Foale RA, Hadjiloizou N, Malik IS, Mikhail GW, Sethi A, Kaprielian R, Baker CS, Lefroy D, Bellamy M, Al-Bustami M, Khan MA, Hughes AD, Francis DP, Mayet J, Di Mario C, Redwood S, Davies JE.
EuroIntervention. 2012 Aug 25. doi:pii: 20120413-02. [Epub ahead of print]
iFR-FFR Hybrid – Ricardo Petraco
Hybrid iFR-FFR decision-making strategy: implications for enhancing universal adoption of physiology-guided coronary revascularisation
Ricardo Petraco MD*, Jin Joo Park¤, Sayan Sen MBBS*, Sukhjinder Nijjer MBChB*, Iqbal S. Malik MBBS PhD*, Mauro Echavarr’a-Pinto MDà, Kaleab N. Asrress MA BM BCh´, Chang-Wook Nam**, Enrico Mac’as MDà, Rodney A Foale MD*, Amarjit Sethi MBBS PhD*, Ghada W. Mikhail MBBS MD*, Raffi Kaprielian MBBS MD*, Christopher S. Baker MBBS PhD*, David Lefroy MB BChir*, Michael Bellamy MBBS MD*, Mahmud Al-Bustami MD*, Masood A. Khan MB BChir MA*, Nieves Gonzalo MD PhDà, Alun D. Hughes MBBS PhD*, Darrel P. Francis MB BChir MA MD*, Jamil Mayet MBChB MD MBA*, Carlo Di Mario MD PhD^, Simon Redwood MBBS MD´, Javier Escaned MD PhDà, Bon-Kwon Koo¤, and Justin E Davies MBBS PhD*. Eurointervention. December 2012 (in press).
Basal Stenosis Resistance – Tim van de Hoef
Diagnostic accuracy of combined intracoronary pressure and flow velocity information during baseline conditions: adenosine-free assessment of functional coronary lesion severity.
van de Hoef TP, Nolte F, Damman P, Delewi R, Bax M, Chamuleau SA, Voskuil M, Siebes M, Tijssen JG, Spaan JA, Piek JJ, Meuwissen M.
Circ Cardiovasc Interv. 2012 Aug 1;5(4):508-14. doi: 10.1161/CIRCINTERVENTIONS.111.965707.
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